Cdc14 Phosphatase Promotes TORC1-Regulated Autophagy in Yeast.
Identifieur interne : 000640 ( Main/Exploration ); précédent : 000639; suivant : 000641Cdc14 Phosphatase Promotes TORC1-Regulated Autophagy in Yeast.
Auteurs : Akihiro Kondo [Japon] ; Md Golam Mostofa [Japon] ; Katsuya Miyake [Japon] ; Mashu Terasawa [Japon] ; Islam Nafisa [Japon] ; Akter M S T. Yeasmin [Japon] ; Talukdar Muhammad Waliullah [Japon] ; Tomotake Kanki [Japon] ; Takashi Ushimaru [Japon]Source :
- Journal of molecular biology [ 1089-8638 ] ; 2018.
Descripteurs français
- KwdFr :
- Autophagie (MeSH), Azote (métabolisme), Famille de la protéine-8 associée à l'autophagie (métabolisme), Mitose (MeSH), Phosphatidylinositol 3-kinases (métabolisme), Phosphorylation (MeSH), Protein Tyrosine Phosphatases (métabolisme), Protéines adaptatrices de la transduction du signal (métabolisme), Protéines associées à l'autophagie (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines du cycle cellulaire (métabolisme), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (métabolisme), Stress physiologique (MeSH).
- MESH :
- croissance et développement : Saccharomyces cerevisiae.
- métabolisme : Azote, Famille de la protéine-8 associée à l'autophagie, Phosphatidylinositol 3-kinases, Protein Tyrosine Phosphatases, Protéines adaptatrices de la transduction du signal, Protéines associées à l'autophagie, Protéines de Saccharomyces cerevisiae, Protéines du cycle cellulaire, Saccharomyces cerevisiae.
- Autophagie, Mitose, Phosphorylation, Régulation de l'expression des gènes fongiques, Stress physiologique.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (metabolism), Autophagy (MeSH), Autophagy-Related Protein 8 Family (metabolism), Autophagy-Related Proteins (metabolism), Cell Cycle Proteins (metabolism), Gene Expression Regulation, Fungal (MeSH), Mitosis (MeSH), Nitrogen (metabolism), Phosphatidylinositol 3-Kinases (metabolism), Phosphorylation (MeSH), Protein Tyrosine Phosphatases (metabolism), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (metabolism), Stress, Physiological (MeSH).
- MESH :
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Autophagy-Related Protein 8 Family, Autophagy-Related Proteins, Cell Cycle Proteins, Nitrogen, Phosphatidylinositol 3-Kinases, Protein Tyrosine Phosphatases, Saccharomyces cerevisiae Proteins.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- Autophagy, Gene Expression Regulation, Fungal, Mitosis, Phosphorylation, Stress, Physiological.
Abstract
Cdc14 protein phosphatase is critical for late mitosis progression in budding yeast, although its orthologs in other organisms, including mammalian cells, function as stress-responsive phosphatases. We found herein unexpected roles of Cdc14 in autophagy induction after nutrient starvation and target of rapamycin complex 1 (TORC1) kinase inactivation. TORC1 kinase phosphorylates Atg13 to repress autophagy under nutrient-rich conditions, but if TORC1 becomes inactive upon nutrient starvation or rapamycin treatment, Atg13 is rapidly dephosphorylated and autophagy is induced. Cdc14 phosphatase was required for optimal Atg13 dephosphorylation, pre-autophagosomal structure formation, and autophagy induction after TORC1 inactivation. In addition, Cdc14 was required for sufficient induction of ATG8 and ATG13 expression. Moreover, Cdc14 activation provoked autophagy even under normal conditions. This study identified a novel role of Cdc14 as the stress-responsive phosphatase for autophagy induction in budding yeast.
DOI: 10.1016/j.jmb.2018.04.007
PubMed: 29694832
Affiliations:
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Electronic address: ushimaru.takashi@shizuoka.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan; Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29694832</idno><idno type="pmid">29694832</idno><idno type="doi">10.1016/j.jmb.2018.04.007</idno><idno type="wicri:Area/Main/Corpus">000570</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000570</idno><idno type="wicri:Area/Main/Curation">000570</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000570</idno><idno type="wicri:Area/Main/Exploration">000570</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cdc14 Phosphatase Promotes TORC1-Regulated Autophagy in Yeast.</title><author><name sortKey="Kondo, Akihiro" sort="Kondo, Akihiro" uniqKey="Kondo A" first="Akihiro" last="Kondo">Akihiro Kondo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Mostofa, Md Golam" sort="Mostofa, Md Golam" uniqKey="Mostofa M" first="Md Golam" last="Mostofa">Md Golam Mostofa</name><affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Miyake, Katsuya" sort="Miyake, Katsuya" uniqKey="Miyake K" first="Katsuya" last="Miyake">Katsuya Miyake</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Terasawa, Mashu" sort="Terasawa, Mashu" uniqKey="Terasawa M" first="Mashu" last="Terasawa">Mashu Terasawa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Nafisa, Islam" sort="Nafisa, Islam" uniqKey="Nafisa I" first="Islam" last="Nafisa">Islam Nafisa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Yeasmin, Akter M S T" sort="Yeasmin, Akter M S T" uniqKey="Yeasmin A" first="Akter M S T" last="Yeasmin">Akter M S T. Yeasmin</name><affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Waliullah, Talukdar Muhammad" sort="Waliullah, Talukdar Muhammad" uniqKey="Waliullah T" first="Talukdar Muhammad" last="Waliullah">Talukdar Muhammad Waliullah</name><affiliation wicri:level="1"><nlm:affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author><author><name sortKey="Kanki, Tomotake" sort="Kanki, Tomotake" uniqKey="Kanki T" first="Tomotake" last="Kanki">Tomotake Kanki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510</wicri:regionArea><wicri:noRegion>Niigata 951-8510</wicri:noRegion></affiliation></author><author><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan; Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan. Electronic address: ushimaru.takashi@shizuoka.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan; Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021</wicri:regionArea><wicri:noRegion>Shizuoka 422-8021</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of molecular biology</title><idno type="eISSN">1089-8638</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (metabolism)</term><term>Autophagy (MeSH)</term><term>Autophagy-Related Protein 8 Family (metabolism)</term><term>Autophagy-Related Proteins (metabolism)</term><term>Cell Cycle Proteins (metabolism)</term><term>Gene Expression Regulation, Fungal (MeSH)</term><term>Mitosis (MeSH)</term><term>Nitrogen (metabolism)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Phosphorylation (MeSH)</term><term>Protein Tyrosine Phosphatases (metabolism)</term><term>Saccharomyces cerevisiae (growth & development)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Stress, Physiological (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie (MeSH)</term><term>Azote (métabolisme)</term><term>Famille de la protéine-8 associée à l'autophagie (métabolisme)</term><term>Mitose (MeSH)</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Phosphorylation (MeSH)</term><term>Protein Tyrosine Phosphatases (métabolisme)</term><term>Protéines adaptatrices de la transduction du signal (métabolisme)</term><term>Protéines associées à l'autophagie (métabolisme)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Protéines du cycle cellulaire (métabolisme)</term><term>Régulation de l'expression des gènes fongiques (MeSH)</term><term>Saccharomyces cerevisiae (croissance et développement)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Stress physiologique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Autophagy-Related Protein 8 Family</term><term>Autophagy-Related Proteins</term><term>Cell Cycle Proteins</term><term>Nitrogen</term><term>Phosphatidylinositol 3-Kinases</term><term>Protein Tyrosine Phosphatases</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Azote</term><term>Famille de la protéine-8 associée à l'autophagie</term><term>Phosphatidylinositol 3-kinases</term><term>Protein Tyrosine Phosphatases</term><term>Protéines adaptatrices de la transduction du signal</term><term>Protéines associées à l'autophagie</term><term>Protéines de Saccharomyces cerevisiae</term><term>Protéines du cycle cellulaire</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autophagy</term><term>Gene Expression Regulation, Fungal</term><term>Mitosis</term><term>Phosphorylation</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Autophagie</term><term>Mitose</term><term>Phosphorylation</term><term>Régulation de l'expression des gènes fongiques</term><term>Stress physiologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cdc14 protein phosphatase is critical for late mitosis progression in budding yeast, although its orthologs in other organisms, including mammalian cells, function as stress-responsive phosphatases. We found herein unexpected roles of Cdc14 in autophagy induction after nutrient starvation and target of rapamycin complex 1 (TORC1) kinase inactivation. TORC1 kinase phosphorylates Atg13 to repress autophagy under nutrient-rich conditions, but if TORC1 becomes inactive upon nutrient starvation or rapamycin treatment, Atg13 is rapidly dephosphorylated and autophagy is induced. Cdc14 phosphatase was required for optimal Atg13 dephosphorylation, pre-autophagosomal structure formation, and autophagy induction after TORC1 inactivation. In addition, Cdc14 was required for sufficient induction of ATG8 and ATG13 expression. Moreover, Cdc14 activation provoked autophagy even under normal conditions. This study identified a novel role of Cdc14 as the stress-responsive phosphatase for autophagy induction in budding yeast.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29694832</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1089-8638</ISSN><JournalIssue CitedMedium="Internet"><Volume>430</Volume><Issue>11</Issue><PubDate><Year>2018</Year><Month>05</Month><Day>25</Day></PubDate></JournalIssue><Title>Journal of molecular biology</Title><ISOAbbreviation>J Mol Biol</ISOAbbreviation></Journal><ArticleTitle>Cdc14 Phosphatase Promotes TORC1-Regulated Autophagy in Yeast.</ArticleTitle><Pagination><MedlinePgn>1671-1684</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0022-2836(18)30220-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jmb.2018.04.007</ELocationID><Abstract><AbstractText>Cdc14 protein phosphatase is critical for late mitosis progression in budding yeast, although its orthologs in other organisms, including mammalian cells, function as stress-responsive phosphatases. We found herein unexpected roles of Cdc14 in autophagy induction after nutrient starvation and target of rapamycin complex 1 (TORC1) kinase inactivation. TORC1 kinase phosphorylates Atg13 to repress autophagy under nutrient-rich conditions, but if TORC1 becomes inactive upon nutrient starvation or rapamycin treatment, Atg13 is rapidly dephosphorylated and autophagy is induced. Cdc14 phosphatase was required for optimal Atg13 dephosphorylation, pre-autophagosomal structure formation, and autophagy induction after TORC1 inactivation. In addition, Cdc14 was required for sufficient induction of ATG8 and ATG13 expression. Moreover, Cdc14 activation provoked autophagy even under normal conditions. This study identified a novel role of Cdc14 as the stress-responsive phosphatase for autophagy induction in budding yeast.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kondo</LastName><ForeName>Akihiro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mostofa</LastName><ForeName>Md Golam</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyake</LastName><ForeName>Katsuya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terasawa</LastName><ForeName>Mashu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nafisa</LastName><ForeName>Islam</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeasmin</LastName><ForeName>Akter M S T</ForeName><Initials>AMST</Initials><AffiliationInfo><Affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waliullah</LastName><ForeName>Talukdar Muhammad</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanki</LastName><ForeName>Tomotake</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ushimaru</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422-8021, Japan; Course of Biological Science, Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8021, Japan. Electronic address: ushimaru.takashi@shizuoka.ac.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>04</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Mol Biol</MedlineTA><NlmUniqueID>2985088R</NlmUniqueID><ISSNLinking>0022-2836</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C413216">ATG13 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C113757">ATG8 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071190">Autophagy-Related Protein 8 Family</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071183">Autophagy-Related Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C074860">CDC14 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018797">Cell Cycle Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.-</RegistryNumber><NameOfSubstance UI="D019869">Phosphatidylinositol 3-Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber><NameOfSubstance UI="C083324">TOR1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.48</RegistryNumber><NameOfSubstance UI="D017027">Protein Tyrosine Phosphatases</NameOfSubstance></Chemical><Chemical><RegistryNumber>N762921K75</RegistryNumber><NameOfSubstance UI="D009584">Nitrogen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D048868" MajorTopicYN="N">Adaptor Proteins, Signal Transducing</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000071190" MajorTopicYN="N">Autophagy-Related Protein 8 Family</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071183" MajorTopicYN="N">Autophagy-Related Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018797" MajorTopicYN="N">Cell Cycle Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008938" MajorTopicYN="N">Mitosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019869" MajorTopicYN="N">Phosphatidylinositol 3-Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017027" MajorTopicYN="N">Protein Tyrosine Phosphatases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Cdc14</Keyword><Keyword MajorTopicYN="Y">Saccharomyces cerevisiae</Keyword><Keyword MajorTopicYN="Y">autophagy</Keyword><Keyword MajorTopicYN="Y">target of rapamycin complex 1 (TORC1)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>03</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>04</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>04</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29694832</ArticleId><ArticleId IdType="pii">S0022-2836(18)30220-1</ArticleId><ArticleId IdType="doi">10.1016/j.jmb.2018.04.007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kondo, Akihiro" sort="Kondo, Akihiro" uniqKey="Kondo A" first="Akihiro" last="Kondo">Akihiro Kondo</name></noRegion><name sortKey="Kanki, Tomotake" sort="Kanki, Tomotake" uniqKey="Kanki T" first="Tomotake" last="Kanki">Tomotake Kanki</name><name sortKey="Miyake, Katsuya" sort="Miyake, Katsuya" uniqKey="Miyake K" first="Katsuya" last="Miyake">Katsuya Miyake</name><name sortKey="Mostofa, Md Golam" sort="Mostofa, Md Golam" uniqKey="Mostofa M" first="Md Golam" last="Mostofa">Md Golam Mostofa</name><name sortKey="Nafisa, Islam" sort="Nafisa, Islam" uniqKey="Nafisa I" first="Islam" last="Nafisa">Islam Nafisa</name><name sortKey="Terasawa, Mashu" sort="Terasawa, Mashu" uniqKey="Terasawa M" first="Mashu" last="Terasawa">Mashu Terasawa</name><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name><name sortKey="Waliullah, Talukdar Muhammad" sort="Waliullah, Talukdar Muhammad" uniqKey="Waliullah T" first="Talukdar Muhammad" last="Waliullah">Talukdar Muhammad Waliullah</name><name sortKey="Yeasmin, Akter M S T" sort="Yeasmin, Akter M S T" uniqKey="Yeasmin A" first="Akter M S T" last="Yeasmin">Akter M S T. Yeasmin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
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{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29694832
|texte= Cdc14 Phosphatase Promotes TORC1-Regulated Autophagy in Yeast.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
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